M. officinalis is native to Europe, central Asia and Iran, but is now naturalized around the world.
Lemon balm seeds require light and at least 20°C (70°F) to germinate. Lemon balm grows in clumps and spreads vegetatively, as well as by seed. In mild temperate zones, the stems of the plant die off at the start of the winter, but shoot up again in spring. Lemon balm grows vigorously and should not be planted where it will spread into other plantings.