The most recent review by Tao et al60 showed a moderate evidence that GLN supplementation can reduce infections and a low quality evidence that GLN supplementation reduces length of hospital stay for critically ill patients. They reported no effect on the risk of mortality and length of ICU stay in the overall results and in subgroup analyses. Again, the main difference with the present analysis is the different study selection criteria. Tao et al included quasi random studies, RCTs on burn patients,52,61–67 trials written in Chinese,68–71 1 trial written in Hungarian,72 1 trial with multiple doses of GLN,73 and 1 trial
without clinical outcomes74 and did not include 10 studies that we found relevant