Results of the meta-analysis of pooled data from 7 clinical studies in a Cochrane systematic review of fluoride varnish
showed an average reduction of 46% and 33% in caries increment in the permanent and primary teeth of children, respectively (Marinho et al., 2002). Advantages of using fluoride varnish include its safety and ability to be applied to specific tooth surfaces or sites with higher caries risk. The amount of fluoride applied is controlled by the operator, making it safe for use in young children below the age of 6 years (Miller and Vann, 2008) and appropriate for people with special needs (Weintraub, 2003).