Nevertheless, biological performances analyses let appear the important role of SRT with an optimal SRT closed to 30d for the chosen OLR in term of COD removal and gas production. Moreover, SRT let also appears determining in term of final separation step by porous membranes. Indeed this separation step if often the weak point of submerged MBR due to the difficulty to control membrane fouling dynamic during operation. Due to the importance of biomass concentration and soluble fraction in methanogenic reactor, such a control should be the limiting point of AnMBR development. The importance of membrane to get a so important global retention of COD confirms the risk of accumulation of large amount of matter onto the membrane surface when filtering such complex suspension. It is then important to analyse specifically the membrane separation step to have a better idea of the SAnMBR challenge to treat POME effluent.