Resveratrol—a natural polyphenolic compound—was first discovered in the 1940s. Although initially used
for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases.
A large part of these effects are related to its antioxidant properties. Here we review: (a) the
sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate
redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its
protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders
such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this
review is to discuss the frontiers in the field of resveratrol’s mechanisms, bioactivity, biology, and healthrelated
use.
Resveratrol—a natural polyphenolic compound—was first discovered in the 1940s. Although initially usedfor cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases.A large part of these effects are related to its antioxidant properties. Here we review: (a) thesources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulateredox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) itsprotective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorderssuch as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of thisreview is to discuss the frontiers in the field of resveratrol’s mechanisms, bioactivity, biology, and healthrelateduse.
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