The experimental work showed that the rutting depth for the modified specimens with polymers is lower than unmodified specimens at any percent of natural sand content and all test condition due to use of polymer modifier increased the stiffness of the binder at high pavement service temperature. The possibility of using natural sand specially desert sand with ratio exceed 25% by weight of the sand passing sieve no. 8 and retained on sieve no 200 for modified asphalt concrete mixes by polymers. Keywords: modified asphalt mixture performance, natural sand content, wheel track test