Non-surgical debridement involves use of agents such as Intrasite Gel (S & N Hlth), Debrisan (Pfizer), or Aserbine (Distriphar), which remove debris without damage to new granulation tissue via the establishment of an osmotic gradient within the wound. Although still often used in animals, wet to dry bandaging of wounds for nonsurgical debridement is contra-indicated. This procedure involves the use of moistened gauze swabs packed into the wound and covered by open weave bandage or gauze and allowed to dry. When dry, removal of the packing will inevitably lead to destruction of some regenerating healthy tissue.