The present study was designed to assess the cytotoxicity, anti-inflammatory and analgesic
properties of methanol extract of Woodfordia fruticosa flowers. Cytotoxic activity of methanol
extract of Woodfordia fruticosa flowers was tested using Artemia salina (Brine shrimp) bioassay
Two doses (400 and 600 mg/Kg) were evaluated for the anti-inflammatory activity against the
carrageenan, histamine, dextran, serotonin and formaldehyde-induced rat paw edema, cotton
pellet-induced granuloma and formaldehyde-induced analgesia in rats. In cytotoxicity study.
extract caused 73% mortality of Brine shrimp larvae after 24 h at a concentration of 1000
ug/mL. The results of the anti-inflammatory study showed that the extract produced significant
p 0.05) decrease in paw volume in different models of paw edema. The extract also inhibited
the formation of granuloma in cotton pellet-induced granuloma and reduced the frequency
of formaldehyde-induced paw licking. These results showed that the methanol extract of
Woodfordia fruticosa flowers have weak cytotoxic and potent anti-inflammatory compounds
and justifies the traditional uses for the treatment of inflammatory conditions
Keywords
Woodfordia fruticosa, Cytotoxicity; Anti-inflammatory; Carrageenan
Histamine; Dextran; Cotton pellet