Although, the concept of stem-cells is present for a longtime, the therapeutic use of the same was first demonstrated
in mouse, where the team used it as the radiation protection
phenomenon (mid-1950s), and it went on for testing in the
dog. For the first time, it was done successfully in the humans
by E. Donnall Thomes, which is the beginning of the modern
era of hematopoietic stem-cell transplantation (HSCT)