Results from a recent pooled analysis of large cohort studies indicated that, when compared calorie-for-calorie, there was a statistically significant greater relative risk for CHD with carbohydrate versus SFA (Fig. 2).12 When the comparison was made between n-6 PUFA and SFA, PUFA intake was associated with a statistically significant lower CHD risk. This result was similar to the original Nurses’ Health Study, ie, that the relation of SFA intake to CHD risk depended on the comparator.