Hydrogel patches were successfully used in an effort to ensure
that the resveratrol stayed at the site of interest, instead of
diffusing into the body. Already, a number of resveratrol supplemented
skin care products and cosmetics are available in the market.
However, these products have not been rigorously tested for
their claims. One problem with the resveratrol formulation of used
in cosmetics is that in order to allow resveratrol to incorporate into
the creams or oils, usually microparticles are used that supposedly
prolong its release into the skin. The drawback of this approach is
that it also reduces the amount of resveratrol available for penetration
into the skin. Recently, Kobierski et al. have tried using several
different stabilizers and surfactants to produce a stable nanosuspension
of resveratrol, and found that two of the non-ionic stabilizers
they tested worked very well [91]. The nano-formulations can
possibly improve resveratrol transport across the membrane as
well as increase solubility. These nanosuspensions were also found
to be stable at room temperature for at least 30 days