The paper investigates the effects of infill density, orientation, and gamma radiation on the mechanical properties of FDM-printed PLA parts in the field of medicine. The key point observed is that compressive properties outperform tensile properties and emphasizes the influence of infill density and orientation on material characteristics. The study recommends specific infill density levels for parts under different loads and underscores the importance of considering gamma radiation sterilization in medical device manufacturing. These finding will be beneficial to improve the global knowledge about FDM parameters, and thus optimize the production of effective medical devices.