We have found that, three synthetic EA analogs and two synthetic
DHEA analogs exhibit a selective inhibitory effect against
HSV-1. Additionally, HSV-1 manipulation of the Raf/MEK/ERK signaling
pathway was studied. In this context, we found that
UO126 and anisomycin, two Raf/MEK/ERK signaling pathway modulators,
could inhibit or enhance viral multiplication, respectively.
DHEA or E2 treatment resulted in an inhibition of viral protein synthesis
and a reduction in virus release. DHEA