At day 7,various titers of recombinant adenoviral vectors were injected intra tumorally in 50 p,l of 10 mM Tris-HCL (pH 7.4)/1 mM MgCl2/10% (vol/vol) glycerol/Polybrene (20 ,tg/ml). All experiments were performed in accordance with the animal guidelines at Baylor College of Medicine.