The role of PDI in thrombus formation was also studied in
a thrombosis model in which vessel injury was initiated with
ferric chloride (Fig. 5). PDI antigen, not detected in the intact
arteriole of the mesentery, accumulated at the site of injury.
PDI antigen expression in the injured arteriole peaked at
approximately 5 min and then slowly decreased. Thus, PDI
antigen is expressed extracellularly during FeCl3-initated
thrombus formation as well as following laser-induced
thrombus formation.