d-Mannitol ( polymorph) was obtained from Fluka Analytical and used directly. The structures of d-mannitol polymorphs are shown in Fig. 1. BMS-A is a corticotrophin releasing factor-1 (CRF-1) receptor antagonist developed for the treatment of depression and anxiety disorders. Five different polymorphs were discovered during chemical development and screening of BMS-A. All five polymorphs were sourced in-house (BMS) and are shown in Fig. 2.