When compared to baseline, IL-6 and haptoglobin concentrations increased in response to LPS administration, irrespective of
thermal conditions. However, during the LPS challenge, the pattern
of these responses differed between the TN and HT groups. According to our results, the magnitude of the IL-6 increase following the
first LPS injection was greater in pigs kept at TN than those at HT.
Pigs kept at TN had persistently elevated circulating haptoglobin
during the LPS challenge, whereas at HT a gradual decrease in haptoglobin values was observed throughout the experimental period.
Since the circulating concentrations of pro-inflammatory cytokines
and haptoglobin reflect the intensity of immune activation and the
severity of inflammation (Murata et al., 2004), we propose that
the immune system of those pigs kept at TN was more sensitive to
the LPS challenge.
When compared to baseline, IL-6 and haptoglobin concentrations increased in response to LPS administration, irrespective ofthermal conditions. However, during the LPS challenge, the patternof these responses differed between the TN and HT groups. According to our results, the magnitude of the IL-6 increase following thefirst LPS injection was greater in pigs kept at TN than those at HT.Pigs kept at TN had persistently elevated circulating haptoglobinduring the LPS challenge, whereas at HT a gradual decrease in haptoglobin values was observed throughout the experimental period.Since the circulating concentrations of pro-inflammatory cytokinesand haptoglobin reflect the intensity of immune activation and theseverity of inflammation (Murata et al., 2004), we propose thatthe immune system of those pigs kept at TN was more sensitive tothe LPS challenge.
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