Descriptive statistics were used to evaluate demographic and medical characteristics of patients. Differences in demographic and medical characteristics between intervention and control group were assessed using Chi-squared and Fisher's exact test for nominal variables, and t-test for continuous variables. Kaplan–Meier method was used for the intent to treat analysis of EFS estimate. EFS at 3 years was measured from date of diagnosis until first date of treatment failure (treatment abandonment, toxic death, progressive, or relapsed disease) or the date of last follow-up.