Characteristics of Depressed Mothers and Their Children There were no significant differences in mothers’ or children’s demographic or clinical characteristics at baseline by maternal treatment (see Table S1 in the online data supplement), with the following exceptions. Mothers who received combination treatment were older on average than those who received one of the monotherapies (mean age, 43.7 years [SD=6.4] for the combination treatment group, compared with 39.9 years [SD=5.6] for the bupropion group and 38.2 [SD=5.7] for the escitalopram group; p=0.003), and 20% of mothers treated with bupropion were married or cohabitating, as compared with 52% of mothers who received either escitalopram or combination treatment. A significantly lower proportion of children of mothers who received bupropion were girls (20% in the bupropion group, compared with 50% in the combination treatment group and 61% in the escitalopram group; p,0.001). There were no significant differences in children’s depressive symptom scores(ontheCDI)or impairment scores (on the CIS) or in proportion with current or lifetime psy-chiatric diagnoses at baseline. Analyses of both mothers’ and children’s outcomes were adjusted for these demographic differences