Our aim was to test whether tungstate improves glucose homeostasis in these genetically obese and diabetic rats. Oral administration of tungstate for 2 months to male ZDF rats initially reverted hyperglycemia. Although this was not a permanent effect, these treated animals never reached the very high glucose levels observed in untreated rats. In addition, the administration of tungstate decreased the elevated serum triglyceride levels. These results show that tungstate is also an effective antidiabetic agent in this type 2 diabetes genetic model.