Based on these findings, Selko Feed Additives and Nutreco R&D together developed TOXO-XL (hereafter called 'biopolymer'), a feed additive which combines multiple protection mechanisms that go beyond binding mycotoxins. Next to a smectite based binder and effective immunity supporting components, the product contains a specific glucose biopolymer that enforces the natural intestinal barrier and reduces mycotoxin induced tight junction damage. In order to prove the efficacy, a series of trials was done in which the effect on animals receiving mycotoxin contaminated feeds was measured. The focus was especially on the ability of the 'biopolymer' to strengthen the gut wall and to reduce absorption of potentially harmful substances.
A first study showed that the 'biopolymer' was successful in maintaining a healthy status during consumption of maximum EU levels of DON, ZEA and OTA contaminated feed by weaned piglets. Adding these mycotoxins to the feed led to an increase in gene expression of the tight junction proteins claudin and occludin