Recently, confirmed that downregulation of ERG9 (ergosterol biosynthesis-pathway gene 9)
, a
gene that encodes SQS in yeast, using a methionine-repressible
promoter (PMET3), increased the production of amorpha-4,11-
diene 2-fold in a yeast strain into which FPP-synthetic-pathway
genes and the ADS (amorpha-4,11-diene synthase) gene from
A. annua L. had been incorporated