CDC applications build from ACS prospective data (tobacco) to
generate estimates of cancer burden for the nation and for states. Thus
the ACS cohorts, like other cohorts, have contributed substantially
to the discovery of public health and biologically important relations
between smoking and cancer . Likewise, the early report by
Thun on the relation of aspirin to reduced colon cancer mortality
opened a field of study that has included subsequent randomized
trials and further observational data to document the
substantial reduction in risk with regular long term use of aspirin