Flexible space system design methods are slated to enable adaptation of Bio-Suit hardware and software elements in the context of changing mission requirements. Reliability can be assured through dependence of Bio-Suit layers acting on local needs and conditions through self-repair at localized sites while preserving overall system integrity. The Bio-Suit System is relevant to NASA's strategic plan and stated visionary challenges in the Human Exploration and Development of Space, AeroSpace Technology, and Space Science.