As a smooth and deformable sickled cell with blunt edges, the POSC
may be the circulating sickle cell type that explains why steady-state patients with as high as 78% POSCs and ISCs do not have VOEs. However,
since the fragmented deoxy-Hb Sfibers in POSCs act as nuclei for the
formation of dense deoxy-Hb Sfibers without a delay time