SAM-e E"cacy
Fourteen English language citations of placebocontrolled
studies of SAM-e monotherapy for the
treatment of depressive symptoms were identi-
fied.107-120 Study quality was a common issue; no
study met all of the study selection criteria
outlined, with most being deficient in regards to
more than one selection criterion. Nevertheless,
because these studies represent the only placebocontrolled
data identified by the searches, they
were utilized for this efficacy examination.
Nine of 14 identified studies included subjects
with mild-to-moderate depressive symptoms
(Table 6) and five included subjects with moderateto-severe
symptoms (Table 7). Only six of the 14