This essay reports scale-up experiments performed in the facilities of University of Aveiro and Natex [37], where extractors of 0.5, 5.0 and 80 L are included. The SFE of E. globulus deciduous bark is accomplished with SC-CO2 modified with ethanol(cosolvent), taking into account relevant information from previous essays [13,35,36]. Several extraction curves are measured together with the TTAs concentration in the extracts along time. Modeling is also accomplished, being fundamental to identify the prevail-ing mass transfer mechanism and establish the appropriate scale