type 2 DM population. The insulin secretion problem in NODAT patients may also explain why vildagliptin had a more pronounced effect on 2HPG rather than FPG. Based on the difficulty to diagnose NODAT by FPG (45), we decided to perform OGTTs to diagnose NODAT, and furthermore, as the primary endpoint.
Because NODAT is a common and severe complication after kidney transplantation and associated with increased morbidity, mortality and graft loss (1–5), novel strategies both to prevent and treat NODAT are highly warranted. Several antidiabetic drugs used in type 2 DM, however, seem unsuitable for transplanted patients (5,9). For example, regarding metformin use, a prospective study in KTRs is required to address whether the risk for lactic acidosis is outweighed by beneficial effects on glucose metabolism (5,12). Thiazolidinediones are currently under
type 2 DM population. The insulin secretion problem in NODAT patients may also explain why vildagliptin had a more pronounced effect on 2HPG rather than FPG. Based on the difficulty to diagnose NODAT by FPG (45), we decided to perform OGTTs to diagnose NODAT, and furthermore, as the primary endpoint.Because NODAT is a common and severe complication after kidney transplantation and associated with increased morbidity, mortality and graft loss (1–5), novel strategies both to prevent and treat NODAT are highly warranted. Several antidiabetic drugs used in type 2 DM, however, seem unsuitable for transplanted patients (5,9). For example, regarding metformin use, a prospective study in KTRs is required to address whether the risk for lactic acidosis is outweighed by beneficial effects on glucose metabolism (5,12). Thiazolidinediones are currently under
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