Arthropod-mediated transmission of arbovirus is initiated when a blood-feeding female injects the virus into the human skin(reviewed in Ref. (48) Like many other members of the flavivirus family. ZIKV is transmitted following the bite of Aedes mosquitoes [15.16]. Different cells types, such as epidermal keratinocytes[49]. dendritic cells [50] or neurons [51] are known to be a target of flaviviruses. Given the knowledge on the entry route of flaviviruses, potential target cells for infection with ZIKV have been investigated. Recently, we have reported that various cells in the human skin compartment are able to support ZIKV replication[47].