Both EEOA and ursolic acid inhibited LPS-stimulated protein and mRNA expression of
both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in these cells. These
results demonstrate that EEOA and its bioactive compound, ursolic acid, suppress LPS-induced NO
and PGE2 production by inhibiting ROS generation, along with reducing expression of iNOS and
COX-2 in RAW 264.7 cells.