Dementia
– Progressive failure of multiple cerebral functions
– Reduction in intellectual function, decreased orientation, recent memory loss, decreased language function, change in behavior
Etiology: trauma, vascular disorders, infections, and Alzheimer’s Dz
• Vascular – Lewy Bodies, Lacunar infarcts
Pathophysiology
• Multiple infarcts with actual destruction of cortical tissue
• Decrease in NT Acetylcholine with abnormalities in amyloid production and deposition
Dementia
– Progressive failure of multiple cerebral functions
– Reduction in intellectual function, decreased orientation, recent memory loss, decreased language function, change in behavior
Etiology: trauma, vascular disorders, infections, and Alzheimer’s Dz
• Vascular – Lewy Bodies, Lacunar infarcts
Pathophysiology
• Multiple infarcts with actual destruction of cortical tissue
- อะเซทิลโคลีนลดลงใน NT กับความผิดปกติของการผลิตและการตกสะสมของแอมีลอยด์
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