This work was supported by the Irish Research Council for Science, Engineering and Technology, co-funded by Marie Curie Actions under FP7; and by Enterprise Ireland Grant Number CC20080001 (Food for Health Ireland). We thank Gavin Conant (University of Missouri, Columbia) for his helpful and valuable comments. We also thank Dick Fitzgerald (University of Limerick, Castletroy, Co. Limerick, Ireland) and Fergal Casey (Novartis Institute of Biomedical Research, Emeryville, CA) for useful discussion.