3. Results
3.1. Effect of intracerebroventricular 6-OHDA injection
on spleen lymphoproliferative response in PCM rats
Fig. 1A shows a significant enhancement of lymphoproliferative
response of PCM rats treated with 6-
OHDA i.c.v. as compared with solvent injected animals
and with untreated PCM group (P < 0.05, Kruskal-
Wallis test). Lymphoproliferative response of 6-OHDA
treated PCM animals was similar to that of untreated
well-nourished rats (Fig. 1BI.
Malnourished untreated rats show a significant depression
of lymphoproliferative response when comfipared with untreated and solvent injected wellnourished
controls (P < 0.01, Mann-Whitney test).
Well-nourished animals treated with 6-OHDA experienced
an increase of their spleen lymphoproliferative
response when compared with solvent-injected and with
untreated controls (Fig. 1B). However, the difference
did not reach statistical significance (Fig. 1B).