Nickel is a nutritionally essential trace metal for at least several animal species, micro-organisms and plants, and therefore either deficiency or toxicity symptoms can occur when, respectively, too little or too much Nikel is taken up. Although a number of cellular effects of nickel have been documented, a deficiency state in humans has not been describ.Nickel and nickel compounds have many industrial and commercial uses, and the progress of industrialization has led to increased emission of pollutants into ecosystems. Although Nikel is omnipresent and is vital for the function of many organisms, concentrations in some areas from both anthropogenic release and naturally varying levels may be toxic to living organisms