In conclusion, DCC resulted in significant health benefits for term and preterm infants. DCC was not associated with any clinically significant difference in the risk of post-operative hemorrhage, neonatal hyperbilirubinemia or symptomatic polycythemia compared to ECC. DCC in preterm and term infants was feasible and safe, and there should be no hesitation in implementing this procedure routinely. Due to the side effects of DCC for 45 s affecting cord blood acid–base parameters and DCC for more than 60 s reducing clinically useful cord blood units (CBUs), further studies are needed to conduct to determine the optimal cord clamping time.