Summary Context: Sacha Inchi (Plukenetia volubilis L.) is a potential oilseed crop because is rich in α-linolenic acid (ALA) (omega-3 fatty acid). Objective: To evaluate the exposure of fatty acids after a single oral administration of sacha inchi or sunflower oil in healthy volunteers. Material and Methods: Plasma fatty acids concentrations were assayed by Gas Chromatography with flame ionization detector in 18 adult subjects. After fasting, blood samples were obtained at 0,0.5,1,2,4,8 and 24-h after ingestion of 10 or 15 ml of sacha inchi oil or sunflower oil. Results: The proportion ALA/Linoleic acid was 1.37 in sacha inchi oil and 0.01 in sunflower oil. ALA, lauric acid, palmitic acid, Linolelaidic acid, Cis 8,11,14-eicosatrienoic acid, Cis-13,16-docosadienoic acid and Cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) levels changed over time after sacha inchi oil ingestion but not with sunflower oil. The time at maximal concentration (Tmax) for ALA was 2-h after sacha inchi oil ingestion. No ALA in plasma was observed after sunflower oil consumption. The maximal concentration of ALA was 2.84±0.36 in women and 0.94 ±0.57 mg/ml in men, P<0.05 whereas, maximal concentration of DHA was 2.60±0.84 mg/ml in women and 1.00±0.38 mg/ml in men (P>0.05). There is a trend for higher plasma ALA levels with 15 ml sacha inchi oil. After 2-h of consumption, plasma delta triacylglycerol (TAG) were reduced with sunflower oil but slightly increased with sacha inchi oil. A reduction in plasma delta TRL-cholesterol was observed with both oils. Conclusion: Consumption of sacha inchi oil increased ALA and DHA in plasma.
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