Chemotherapy is commonly used for the treatment of cancer, delaying its progression and relieving pain. Although
chemotherapy can contribute to complete resolution and life extension in cancer patients, it has many adverse
effects and can cause significant problems, which are often neglected.Widely used platinum compounds, taxanes, and vinca alkaloids are now known to induce peripheral neuropathy, and chemotherapy-induced peripheral neuropathy (CIPN) has been reported in more than 30%to 40%of patients who were treated with multiple chemotherapeutic agents.1 The incidence and severity of CIPN depend on the types of agents and cumulative doses, and the pain due to CIPN is caused by damage to the peripheral and central nervous systems. Patients complain of a ‘‘burning, cold, numb’’ pain.