The multivariate perspective provides further insights into the pathophysiological changes in AD. The SCP not only suggests basal and brainstem cholinergic system deficits, but DMN, salience and Papez cholinergic circuits may also be vulnerable, and that the cholinergic system might have a more fundamental role in the normal functioning of these networks in AD. Future studies could examine the cholinergic network profiles that are associated with positive treatment outcomes from therapies aimed at improving cholinergic neurotransmission.