Physical connectivity is the basic for the ASEAN cooperation to be a community. This paper studies the readiness of Mukdahan province for a special economic zones. It shows that developing Mukdahan physical connectivity, will provide the advantages by strange and opportunity to develop the province for tourism, employment and transportation but challenge for thread and weakness for future profitability should also be considered such as business computers and cross-border crimes, strategy of the urban expansion. The enterprises should improve themselves to reach the international standards.