According to proposed by us the consequence of events in atherosclerosis, intracellular lipid accumulation induced by modified LDL should be considered as the crucial event of atherogenesis. Lipid accumulation stimulates the major atherosclerotic manifestations,atthe same time associates of modified LDL destroy cellular network in the intima by stimulating phagocytosis. This leads to the formation of pronounced lipid-rich lesions, namely, fatty streaks or fibrolipid plaques, where the intensity of atherogenic manifestations at the cellular level shows the maximum.