In seven studies (more than 3000 women), the group with prophylactic administration of oxytocin presented significant differences in decreases of blood loss compared with the control group In six trials (with more than 2800 women), there was little evidence of
the effects of oxytocin and ergot alkaloids; however, oxytocin was associated with a smaller number of manual removal of placenta and lower elevated blood pressure In five studies (more than 2800 women), there was little evidence of a synergistic effect of oxytocin in association with ergometrine compared with the isolated use of
ergometrine