of weeks. A recent metinalyws in esophagitis showed that Pvis exhibit better healing effect and faster symptom relief than histamine recevtor antago f nists (H2RAs), which are in turn better than placebo The success rate of esophagitis healing was 83% after weeks of therapy. Moreover, ppis are effective for maintenance of healing and symptom control in patients who respond to an acute course of therapy for a period of 6 12 months (49, 90). Whether one is superior to che other is a matter of matter of controversy. Although data suggest differences among various PPIs with respect to healing rates 191], absolute differences in efficacy are very modest and more pronounced in patients with severe esophagitis (89), However, individual variability in patient response to PPIs varies widely and in patients not responding