Our analysis of the debris removal program in Biscayne National Park successfully enabled us to uncover differences in contractor efficiency, determine that the available in situ debris exceeds the yearly removal effort, and use GIS analysis to generate spatially-explicit debris “hot spots” maps. This approach allowed us to assess the efficiency of the current removal effort, as well as provide a unique tool to target high debris hot spots. The relatively simple spatial analyses employed in this study, in conjunction with the greater availability of remotely-sensed seascape data, make this GIS approach applicable to other resource managers interested in targeting debris removal. Furthermore, the hot spot maps can be readily updated with new data, as it becomes available.