Physical consequences of long-distance flights range from simple swelling of the lower limbs to the formation of dangerous blood clots. Centella’s effectiveness was evaluated in 66 flight passengers (33 men, 33 women; mean age 38) traveling in economy class for 312 hours. Subjects were randomized to receive 60 mg
TTFCA three times per day or a placebo two days before, the day of, and two days after the flight. Results showed significant improvements in microcirculatory function (transcutaneous pO2 and pCO2, laser doppler flowmetry, venoarteriolar response, rate of ankle swelling, and edema) in those utilizing TTFCA (p