Both immediate and delayed hydroceph- alus are possible following IVH,6 yet the mechanisms by which they occur are unclear. Despite improvement in treatment of IVH
and subsequent hydrocephalus in recent years, these conditions are still life- threatening and often lead to death. Mechanistic understanding of the events that lead to IVH and subsequent hydrocephalus will guide both clinical research and basic-science experiments geared towards treating these conditions. Creating a mech- anistic framework is important for clarifying the underlying pathophysiology, identifying targets for intervention and improving the monitoring of progression of IVH. With improved monitoring and means of interven- tion, deterioration of patients’ conditions can be avoided and rate of recovery can be increased. We focus on the mechanism of hydrocephalus after non-traumatic IVH in adults. Although germinal matrix- intraventricular haemorrhage is a frequent phenomenon in premature and very-low- birth-weight (