Failure of an aerospace component can arise through the long term exposure to fatigue damaging events such as large numbers of low amplitude random events and/or relatively fewer high amplitude events. Mission profiling and test synthesis is a process for deriving a simple laboratory test that has at least the same damage potential as the real environment but in a fraction of the real time. In this paper we introduce the technical concepts and present a case study showing how new technology has dramatically reduced the time it takes to prepare and reduce the original test data.