Relation of NYHA class, peak oxygen uptake, six
minute walk test, left ventricular ejection fraction, and
quality of life
In addition to NYHA functional class, more objective indices of
functional capacity—such as peak oxygen uptake and the six
minute walk test—also showed some relation to the quality of
life. This contrasts with the report by Steptoe and
colleagues, who found no univariate association between
exercise capacity and quality of life in patients with mild to
moderate congestive heart failure (predominantly in NYHA
classes I and II); however, our present study included a
broader spectrum of patients with congestive heart failure,
with a large proportion in NYHA class III. Cardiopulmonary
exercise testing and the six minute walk test represent different
aspects of functional capacity, as only the latter—a
submaximal exercise test—reflects the work load of daily
activities. However, in accordance with the close relation
between both these exercise tests, all SF-36 scales were
related similarly to peak oxygen uptake and to the six minute
walk test. In contrast, the left ventricular ejection fraction was
not significantly correlated with any of the short form scales.
Furthermore, there was no difference in health related quality
of life in patients subgrouped according to their ejection fraction.
This finding confirms the lack of relation between left
ventricular ejection fraction and disease specific quality of life
observed in other studies.
The findings of our present study may also explain why b
blocker treatment in congestive heart failure has no consistent
effect on the quality of life, despite a pronounced improvement
in left ventricular ejection fraction (for review, see Carson34),
whereas the increase in peak oxygen uptake achieved
by exercise training is associated with an improvement in
quality of life.
In general, the variance in the short form scales that can be
explained by factors such as NYHA functional class, peak oxygen
uptake, six minute walk test, left ventricular ejection fraction,
age, and the duration of disease was small. Only the variance
of physical functioning was determined to a considerable
degree (51%) by NYHA functional class and the six minute
Relation of NYHA class, peak oxygen uptake, sixminute walk test, left ventricular ejection fraction, andquality of lifeIn addition to NYHA functional class, more objective indices offunctional capacity—such as peak oxygen uptake and the sixminute walk test—also showed some relation to the quality oflife. This contrasts with the report by Steptoe andcolleagues, who found no univariate association betweenexercise capacity and quality of life in patients with mild tomoderate congestive heart failure (predominantly in NYHAclasses I and II); however, our present study included abroader spectrum of patients with congestive heart failure,with a large proportion in NYHA class III. Cardiopulmonaryexercise testing and the six minute walk test represent differentaspects of functional capacity, as only the latter—asubmaximal exercise test—reflects the work load of dailyactivities. However, in accordance with the close relationbetween both these exercise tests, all SF-36 scales wererelated similarly to peak oxygen uptake and to the six minutewalk test. In contrast, the left ventricular ejection fraction wasnot significantly correlated with any of the short form scales.Furthermore, there was no difference in health related qualityof life in patients subgrouped according to their ejection fraction.This finding confirms the lack of relation between leftventricular ejection fraction and disease specific quality of lifeสังเกตในการศึกษาอื่น ๆผลการศึกษาของเราอาจอธิบายว่า ทำไม bรักษาป้องกันหัวใจล้มเหลวได้ไม่สม่ำเสมอผลกระทบต่อคุณภาพชีวิต แม้มีการปรับปรุงที่เด่นชัดในหัวใจที่หัวใจห้องล่างซ้าย (สำหรับรีวิว ดู Carson34),ในขณะที่ทำการเพิ่มการดูดซึมออกซิเจนสูงสุดโดยออกกำลังกาย การฝึกอบรมเกี่ยวข้องกับการปรับปรุงในคุณภาพชีวิตของในทั่วไป ต่างชั่งแบบฟอร์มสั้น ๆ ที่สามารถอธิบายได้ ด้วยปัจจัยต่าง ๆ เช่น NYHA ทำชั้น ออกซิเจนสูงสุดดูดซึม หกนาทีเดินทดสอบ ซ้ายหัวใจห้องล่างของหัวใจอายุ และระยะเวลาของโรคมีขนาดเล็ก ผลต่างเท่านั้นทำงานได้จริงถูกกำหนดเป็นองถนนองศา (51%) โดย NYHA ชั้นทำงานและในนาทีที่หก
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