in this article, we first report on a feasibility study of how to process large quantities of cheese powder materials containing SEA at sub ng/g levels. After successful completion, the processing of raw milk cheese to three candidate reference materials(a blank, a very low spiked and a low spiked material) is decribed together with the homogeneity and short-term stability studies and their evaluation. Finally, we briefly elaborate on the strategy foreseen for material characterisation and value assignment. The presented results constitute an important step towards the development of a certified matrix RM for SEA