Effect of increased Pco2,H+,temperature,and 2,3-bisphosphoglycerate on the O2-Hb curve. Increased Po2,acid,and temperatue,as found at the tissue lavel,shift the O2-Hb curve to the right. As a result,less O2 is unload from Hb for use by the tissue.Similarly,2,3-bisphosphoglycerate,whose production is increased in red blood cells when arterial HbO2 is chronically below normal,shifts the O2-Hb curve to the right, marking more of the limited O2 available at the tissue level.
Effect of increased Pco2,H+,temperature,and 2,3-bisphosphoglycerate on the O2-Hb curve. Increased Po2,acid,and temperatue,as found at the tissue lavel,shift the O2-Hb curve to the right. As a result,less O2 is unload from Hb for use by the tissue.Similarly,2,3-bisphosphoglycerate,whose production is increased in red blood cells when arterial HbO2 is chronically below normal,shifts the O2-Hb curve to the right, marking more of the limited O2 available at the tissue level.
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