Never before has it been so clinically important to understand the predictors and effect of VASCs in PCI, acute coronary syndrome, and STEMI.37 Patients are increasingly treated with higher complexity regimens containing greater numbers of more potent oral and intravenous antiplatelet and antithrombin medications for longer periods. These factors can be expected to result in higher rates of VASCs.35 Critically ill patients admitted to the intensive care unit are at high risk for VASCs because of the presence of comorbid conditions such as renal failure, hypertension, and advanced age. These patients are also more likely to be heavily anticoagulated and to have had a high-risk, technically demanding procedure on an emergency basis.